The First Congressional District of Missouri includes much of St. Louis and its wealthier suburbs. Prestigious Washington University in St. Louis is within the district, which is represented by Democrat William Lacy Clay, Jr. (hw).
2006 election cycle
- William Lacy Clay, Jr. (D): 139,561 73% (cw)
- Mark Joseph Byrne (R): 47,352 25% (cw)
- Robb E. Cunningham (Libertarian): 4,688 2% (cw)
2004 election cycle
- William Lacy Clay, Jr. (D): 212,515, 75%
- Leslie Farr (R): 64,636, 23%